Showcases

PhD thesis "Predicting the long-term effects of mechanical overload to arterial tissue: a chemo-mechano-biological framework" by Lauranne Maes 00:00 Introduction 00:27 Mechanical homeostasis 01:04 Biomechanics of cardiovascular diseases 02:59 Goal 03:41 Modeling arterial tissue 05:16 Predicting healing and degeneration 05:47 Benefits 07:42 Conclusion and outro

FIBEr is organizing a community challenge: C4Bio.eu together with the research and technology working group of Avicenna Alliance and VPH Institute. #insilicomedicine is becoming more important than ever. That is why the need for reliable parameters of biological tissues to develop accurate computer simulations Current parameters show high variability due to the lack of internationally recognized test protocols for biological tissues THE AIM OF C4BIO is: 🚩 achieve community consensus on the testing protocols for material characterization of biological tissue 🚩disseminate this consensus to the relevant standards bodies (i.a. ISO - International Organization for Standardization & ASME (The American Society of Mechanical Engineers) This challenge consists of different testing campaigns each focusing on a single aspect of the whole testing process. The first campaign: UNIAXIAL TENSILE TESTING of soft biological tissue. More information on: https://c4bio.eu/ Partners: - https://avicenna-alliance.com/ - https://www.vph-institute.org/ - https://www.kuleuven.be/english/

Bekijk de pitch waarmee Klaas Vander Linden (KU Leuven - FWO) het zilver behaalde bij de Vlaamse PhD 2024. Meer info over zijn onderzoek op www.phdcup.be/deelnemer/klaas-vander-linden

We are FIBEr. We offer full-service packages for the complete biomechanical study of your tissue or product. "Adequate mechanical testing of your medical device is a key factor for a good long term clinical outcome" Our portfolio of devices and expertise is unique in Europe and allows biomechanical testing of a wide range of products using state-of-the-art methods. FIBEr's experienced researchers will help you to choose the best set-up and testing protocol for your problem. You can find more info on www.kuleuven.be/FIBEr

For the Community challenge, we are printing the C4BIO dogbone cutting and thickness measurement tools. The goal of these tools is to standardize the sample preparation and the thickness measurement of soft tissue for a uniaxial tensile test. Find more information on this initiative on C4BIO.eu Together with the Avicenna Alliance and VPHi Printing by @FablabLeuven

Mechanical characterization of biological tissues is not a trivial task. This video will guide you through the most important aspects of good mechanical testing of biological tissues and medical products which is the core business of Flanders Institute for Biomechanical Experimentation. The key is to create loading conditions that resemble the IN VIVO situation of the human body as closely as possible. These conditions are clearly very different for a skeletal bone than for the brain or the heart. That is why we at FIBEr have a wide range of mechanical testing devices so that we can test along multiple axes if necessary, quasi-statically or dynamically and for tissues as small as a single cell up to large skeletal bones. We take great care to design the perfect loading protocol for every application. For harvesting samples, we closely collaborate with our university hospital. Patient privacy is safeguarded and all samples receive a unique identifier. The dimensions of the sample are measured accurately using a micro-laser scanner. The tissue’s microstructure and how it changes under mechanical loading are measured using a micro CT scanner. During the test, we measure the non-uniform deformation of the sample by applying a speckle pattern to the tissue and using digital image correlation. We mimic the physiological conditions as closely as possible, by performing our tests in physiological solution at body temperature. From the raw experimental data, we can derive typical mechanical properties. We then use this information to quantify the mechanical compatibility of a biomedical product or for in silico modeling. Our team at FIBEr can help you in this challenging process. A process that, with the new medical device regulation in place, is more important than ever. Get in contact with us: www.kuleuven.be/fiber In collaboration with: - KU Leuven - IORT (https://gbiomed.kuleuven.be/english/research/50000640/clustersbe/iort) - Department of mechanical engineering ( https://www.mech.kuleuven.be/en) - Hercules stichting (https://www.fwo.be/)

This video will guide you through a typical workflow of a planar biaxial tensile test performed at FIBEr. When mechanically characterizing biological tissues in vitro, it is essential to create loading conditions that resemble the in vivo loading situation as closely as possible. For quite a number of soft biological tissues, this can be done through planar biaxial tensile testing. You can find more info and our testing services on www.kuleuven.be/fiber

On 7 November 2024, Thibault Vervenne presented their breakthrough idea, Breaking the Wall of Dr. Ross: A Comeback Kid, at the Falling Walls Lab Finale during the Falling Walls Science Summit 2024 in Berlin. Thibault Vervenne is addressing the problem of autograft dilation in the Ross procedure, where the patient's pulmonary valve is placed in the aortic position. By using computational models, he proposes that wrapping the autograft with a biodegradable textile can prevent dilation and restore arterial wall compliance. His goal is to develop biodegradable polymeric structures for this purpose, integrating engineering, medicine, and material science for cardiac surgery applications. 🌐 Learn More About Falling Walls Lab: https://falling-walls.com/lab Explore the playlist with all the Falling Walls Lab Pitches 2024: https://www.youtube.com/playlist?list=PLkhVBjzvMPh1se71GqnXiUxhVx6iTlqK7 📩 Stay Updated: Sign up for our newsletter: https://falling-walls.com/get-involved/newsletter #FallingWallsFoundation #FallingWallsLab #ScienceSummit24

We performed an in vitro inflation test of mouse lungs for the research of Kaveh Ahookhosh and Greetje Vande Velde from KU Leuven It was a first try-out and we are confident that with further optimization we will be able to characterize this complex tissue 💪 🔎 More about this project: In short, these tests are part of the research to improve the early diagnosis of interstitial lung diseases (ILDs) such as lung fibrosis. The researchers have already collected in vivo micro-CT images and functional measurements but are missing pieces of the puzzle. The difference between diseased and healthy regions in the lung are visible on the micro-CT images but not (early enough) in the functional measurements. That is why they want to look at the lung's stiffness and see if this info can be a useful biomarker for onset and progression of ILDs. ADDED VALUE OF FIBEr: We have defined two tests to measure the stiffness of the mice lungs: 1) In vitro inflation (movie below) 2) Stiffness mapping through indentation (not shown) We hope to support these researchers and help them find out how healthy & diseased mouse lungs expand. Do you want mechanical characterization of your tissue or medical device? Get in touch! #Biomechanics #Research #Diagnostics #Lung #Healthcare #Biomedical #mechanobiology

A short video explaining the work of my PhD 'Experimental and numerical analysis of growth and remodeling phenomena in the pulmonary autograft'. The full PhD can be downloaded here: https://lirias.kuleuven.be/retrieve/595329